CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways

CNS germinomas represent a unique germ cell tumor entity characterized by undifferentiated tumor cells and a high response rate to current treatment protocols. Limited information is available on their underlying genomic, epigenetic and biological alterations. We performed a genome-wide analysis of...

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Detalles Bibliográficos
Autores principales: Schulte, Simone Laura, Waha, Andreas, Steiger, Barbara, Denkhaus, Dorota, Dörner, Evelyn, Calaminus, Gabriele, Leuschner, Ivo, Pietsch, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342399/
https://www.ncbi.nlm.nih.gov/pubmed/27391150
http://dx.doi.org/10.18632/oncotarget.10392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342399/
https://www.ncbi.nlm.nih.gov/pubmed/27391150
http://dx.doi.org/10.18632/oncotarget.10392

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