Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development

Nucleophosmin (NPM1) is a ubiquitous multifunctional phosphoprotein with both oncogenic and tumor suppressor functions. Mutations of the NPM1 gene are the most frequent genetic alterations in acute myeloid leukemia (AML) and result in the expression of a mutant protein with aberrant cytoplasmic loca...

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Detalles Bibliográficos
Autores principales: Barbieri, Elisa, Deflorian, Gianluca, Pezzimenti, Federica, Valli, Debora, Saia, Marco, Meani, Natalia, Gruszka, Alicja M., Alcalay, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342418/
https://www.ncbi.nlm.nih.gov/pubmed/27486814
http://dx.doi.org/10.18632/oncotarget.10878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342418/
https://www.ncbi.nlm.nih.gov/pubmed/27486814
http://dx.doi.org/10.18632/oncotarget.10878

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