Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

Pro-inflammatory signaling pathways, especially interleukin 6 (IL-6), and reactive oxygen species (ROS) promote carcinogenesis in the liver. In order to elucidate the underlying oncogenic mechanism, we activated the IL-6 signal transducer glycoprotein 130 (gp130) via stable expression of a constitut...

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Detalles Bibliográficos
Autores principales: Heim, Denise, Gil-Ibanez, Ines, Herden, Johannes, Parplys, Ann Christin, Borgmann, Kerstin, Schmidt-Arras, Dirk, Lohse, Ansgar W., Rose-John, Stefan, Wege, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342442/
https://www.ncbi.nlm.nih.gov/pubmed/27489351
http://dx.doi.org/10.18632/oncotarget.10956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342442/
https://www.ncbi.nlm.nih.gov/pubmed/27489351
http://dx.doi.org/10.18632/oncotarget.10956

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