The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP(3) receptor inhibition

The anti-apoptotic Bcl-2 protein is emerging as an efficient inhibitor of IP(3)R function, contributing to its oncogenic properties. Yet, the underlying molecular mechanisms remain not fully understood. Using mutations or pharmacological inhibition to antagonize Bcl-2's hydrophobic cleft, we ex...

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Detalles Bibliográficos
Autores principales: Ivanova, Hristina, Ritaine, Abigael, Wagner, Larry, Luyten, Tomas, Shapovalov, George, Welkenhuyzen, Kirsten, Seitaj, Bruno, Monaco, Giovanni, De Smedt, Humbert, Prevarskaya, Natalia, Yule, David I., Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342447/
https://www.ncbi.nlm.nih.gov/pubmed/27494888
http://dx.doi.org/10.18632/oncotarget.11005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342447/
https://www.ncbi.nlm.nih.gov/pubmed/27494888
http://dx.doi.org/10.18632/oncotarget.11005

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