Targeting the ERK pathway for the treatment of Cushing's disease

We recently demonstrated that the orphan nuclear receptor testicular receptor 4 (TR4) is a potent regulator of corticotroph tumor growth and hormone secretion. The Ras/Raf/MEK/ERK pathway is commonly overactivated in human tumors and we have demonstrated that corticotroph tumor TR4 is activated by E...

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Detalles Bibliográficos
Autores principales: Zhang, Dongyun, Bergsneider, Marvin, Wang, Marilene B., Heaney, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342466/
https://www.ncbi.nlm.nih.gov/pubmed/27708250
http://dx.doi.org/10.18632/oncotarget.12381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342466/
https://www.ncbi.nlm.nih.gov/pubmed/27708250
http://dx.doi.org/10.18632/oncotarget.12381

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