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Targeting the ERK pathway for the treatment of Cushing's disease

We recently demonstrated that the orphan nuclear receptor testicular receptor 4 (TR4) is a potent regulator of corticotroph tumor growth and hormone secretion. The Ras/Raf/MEK/ERK pathway is commonly overactivated in human tumors and we have demonstrated that corticotroph tumor TR4 is activated by E...

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Detalles Bibliográficos
Autores principales:	Zhang, Dongyun, Bergsneider, Marvin, Wang, Marilene B., Heaney, Anthony P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342466/ https://www.ncbi.nlm.nih.gov/pubmed/27708250 http://dx.doi.org/10.18632/oncotarget.12381

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