The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma

PPM1D is a serine/threonine phosphatase that negatively regulates key DNA damage response proteins, such as p53, p38 MAPK, histone H2A.X, and ATM. We investigated the pathophysiological significance of PPM1D and its therapeutic targeting by the novel PPM1D inhibitor GSK2830371 in mantle cell lymphom...

Descripción completa

Detalles Bibliográficos
Autores principales: Kojima, Kensuke, Maeda, Aya, Yoshimura, Mariko, Nishida, Yuki, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342503/
https://www.ncbi.nlm.nih.gov/pubmed/27626308
http://dx.doi.org/10.18632/oncotarget.11904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342503/
https://www.ncbi.nlm.nih.gov/pubmed/27626308
http://dx.doi.org/10.18632/oncotarget.11904

Ejemplares similares