Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

Two important protein-protein interactions establish E-cadherin (Cdh1) in the adhesion complex; homophilic binding via the extra-cellular (EC1) domain and cytoplasmic tail binding to β-catenin. Here, we evaluate whether E-cadherin binding can inhibit β-catenin when there is loss of Adenomatous polyp...

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Detalles Bibliográficos
Autores principales: Matheson, Julia, Bühnemann, Claudia, Carter, Emma J., Barnes, David, Hoppe, Hans-Jürgen, Hughes, Jennifer, Cobbold, Stephen, Harper, James, Morreau, Hans, Surakhy, Mirvat, Hassan, A. Bassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342522/
https://www.ncbi.nlm.nih.gov/pubmed/27566565
http://dx.doi.org/10.18632/oncotarget.11513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342522/
https://www.ncbi.nlm.nih.gov/pubmed/27566565
http://dx.doi.org/10.18632/oncotarget.11513

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