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Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation

A key hallmark of cancer cells is the loss of positional control over growth and survival. Focal adhesion kinase (FAK) is a tyrosine kinase localised at sites of integrin-mediated cell adhesion to the extracellular matrix. FAK controls a number of adhesion-dependent cellular functions, including mig...

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Detalles Bibliográficos
Autores principales:	Walker, Scott, Foster, Fiona, Wood, Amber, Owens, Thomas, Brennan, Keith, Streuli, Charles H., Gilmore, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342556/ https://www.ncbi.nlm.nih.gov/pubmed/27611942 http://dx.doi.org/10.18632/oncotarget.11856

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