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Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer

Personalized medicine has emerged as the future of cancer care to ensure that patients receive individualized treatment specific to their needs. In order to provide such care, molecular techniques that enable oncologists to diagnose, treat, and monitor tumors are necessary. In the field of lung canc...

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Autores principales: Bennett, Catherine W., Berchem, Guy, Kim, Yeoun Jin, El-Khoury, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342606/
https://www.ncbi.nlm.nih.gov/pubmed/27589834
http://dx.doi.org/10.18632/oncotarget.11717
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author Bennett, Catherine W.
Berchem, Guy
Kim, Yeoun Jin
El-Khoury, Victoria
author_facet Bennett, Catherine W.
Berchem, Guy
Kim, Yeoun Jin
El-Khoury, Victoria
author_sort Bennett, Catherine W.
collection PubMed
description Personalized medicine has emerged as the future of cancer care to ensure that patients receive individualized treatment specific to their needs. In order to provide such care, molecular techniques that enable oncologists to diagnose, treat, and monitor tumors are necessary. In the field of lung cancer, cell free DNA (cfDNA) shows great potential as a less invasive liquid biopsy technique, and next-generation sequencing (NGS) is a promising tool for analysis of tumor mutations. In this review, we outline the evolution of cfDNA and NGS and discuss the progress of using them in a clinical setting for patients with lung cancer. We also present an analysis of the role of cfDNA as a liquid biopsy technique and NGS as an analytical tool in studying EGFR and MET, two frequently mutated genes in lung cancer. Ultimately, we hope that using cfDNA and NGS for cancer diagnosis and treatment will become standard for patients with lung cancer and across the field of oncology.
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spelling pubmed-53426062017-03-24 Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer Bennett, Catherine W. Berchem, Guy Kim, Yeoun Jin El-Khoury, Victoria Oncotarget Review Personalized medicine has emerged as the future of cancer care to ensure that patients receive individualized treatment specific to their needs. In order to provide such care, molecular techniques that enable oncologists to diagnose, treat, and monitor tumors are necessary. In the field of lung cancer, cell free DNA (cfDNA) shows great potential as a less invasive liquid biopsy technique, and next-generation sequencing (NGS) is a promising tool for analysis of tumor mutations. In this review, we outline the evolution of cfDNA and NGS and discuss the progress of using them in a clinical setting for patients with lung cancer. We also present an analysis of the role of cfDNA as a liquid biopsy technique and NGS as an analytical tool in studying EGFR and MET, two frequently mutated genes in lung cancer. Ultimately, we hope that using cfDNA and NGS for cancer diagnosis and treatment will become standard for patients with lung cancer and across the field of oncology. Impact Journals LLC 2016-08-30 /pmc/articles/PMC5342606/ /pubmed/27589834 http://dx.doi.org/10.18632/oncotarget.11717 Text en Copyright: © 2016 Bennett et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Bennett, Catherine W.
Berchem, Guy
Kim, Yeoun Jin
El-Khoury, Victoria
Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title_full Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title_fullStr Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title_full_unstemmed Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title_short Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
title_sort cell-free dna and next-generation sequencing in the service of personalized medicine for lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342606/
https://www.ncbi.nlm.nih.gov/pubmed/27589834
http://dx.doi.org/10.18632/oncotarget.11717
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