The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

Ubiquitin-Specific Proteases (USPs) are deubiquitinating enzymes frequently deregulated in human malignancies. Here, we show that USP54 is overexpressed in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes tumorigenesis. We have generated mutant mice...

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Detalles Bibliográficos
Autores principales: Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Español, Yaiza, Freije, José M.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342676/
https://www.ncbi.nlm.nih.gov/pubmed/27769071
http://dx.doi.org/10.18632/oncotarget.12769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342676/
https://www.ncbi.nlm.nih.gov/pubmed/27769071
http://dx.doi.org/10.18632/oncotarget.12769

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