Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kretzschmar, Christin, Roolf, Catrin, Timmer, Katrin, Sekora, Anett, Knübel, Gudrun, Escobar, Hugo Murua, Fuellen, Georg, Ibrahim, Saleh M., Tiedge, Markus, Baltrusch, Simone, Jaster, Robert, Köhling, Rüdiger, Junghanss, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://www.ncbi.nlm.nih.gov/pubmed/27626489
http://dx.doi.org/10.18632/oncotarget.11952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://www.ncbi.nlm.nih.gov/pubmed/27626489
http://dx.doi.org/10.18632/oncotarget.11952

Ejemplares similares