Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

The glutamate exchanger xCT (SLC7a11) is causally linked with the malignancy grade of brain tumors and represents a key player in glutamate, cystine and glutathione metabolism. Although blocking xCT is not cytotoxic for brain tumors, xCT inhibition disrupts the neurodegenerative and microenvironment...

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Detalles Bibliográficos
Autores principales: Sehm, Tina, Rauh, Manfred, Wiendieck, Kurt, Buchfelder, Michael, Eyüpoglu, IIker Y., Savaskan, Nicolai E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342691/
https://www.ncbi.nlm.nih.gov/pubmed/27612422
http://dx.doi.org/10.18632/oncotarget.11858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342691/
https://www.ncbi.nlm.nih.gov/pubmed/27612422
http://dx.doi.org/10.18632/oncotarget.11858

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