PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells

Increased mRNA translation drives carcinogenesis and is an attractive target for the development of new anti-cancer drugs. In this work, we investigated effects of phenethylisothiocyanate (PEITC), a phytochemical with chemopreventive and anti-cancer activity, on mRNA translation. PEITC rapidly inhib...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeomans, Alison, Lemm, Elizabeth, Wilmore, Sarah, Cavell, Breeze E., Valle-Argos, Beatriz, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Willis, Anne E., Forconi, Francesco, Stevenson, Freda K., Steele, Andrew J., Coldwell, Mark J., Packham, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342703/
https://www.ncbi.nlm.nih.gov/pubmed/27579538
http://dx.doi.org/10.18632/oncotarget.11655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342703/
https://www.ncbi.nlm.nih.gov/pubmed/27579538
http://dx.doi.org/10.18632/oncotarget.11655

Ejemplares similares