Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells

The mechanisms underlying activation of the BET pathway in AML cells remain poorly understood. We have discovered that autophagy is activated in acute leukemia cells expressing mutant nucleophosmin 1 (NPMc+) or MLL-fusion proteins. Autophagy activation results in the degradation of NPM1 and HEXIM1,...

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Detalles Bibliográficos
Autores principales: Huang, Min, Garcia, Jacqueline S., Thomas, Daniel, Zhu, Li, Nguyen, Le Xuan Truong, Chan, Steven M., Majeti, Ravindra, Medeiros, Bruno C., Mitchell, Beverly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342712/
https://www.ncbi.nlm.nih.gov/pubmed/27732946
http://dx.doi.org/10.18632/oncotarget.12493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342712/
https://www.ncbi.nlm.nih.gov/pubmed/27732946
http://dx.doi.org/10.18632/oncotarget.12493

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