Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro

We recently described that the anti-apoptotic AMPK-related kinase, SNARK, promotes transforming growth factor (TGF)-β signaling in hepatocellular carcinoma (HCC) cells, as a potentially new therapeutic target. Here we explored FDA-approved drugs inhibiting the enzymatic activity of SNARK, using an i...

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Detalles Bibliográficos
Autores principales: Goto, Kaku, Kato, Naoya, Chung, Raymond T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342717/
https://www.ncbi.nlm.nih.gov/pubmed/27602492
http://dx.doi.org/10.18632/oncotarget.11820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342717/
https://www.ncbi.nlm.nih.gov/pubmed/27602492
http://dx.doi.org/10.18632/oncotarget.11820

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