An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway

The activated JAK2-STAT3 signaling pathway is a high risk factor for multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, SC09, a potential inhibitor of cholesterol absorption, was identified in a STAT3-targeted drug screen. SC09 suppressed the activation of STAT3 in a ti...

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Detalles Bibliográficos
Autores principales: Xu, Xin, Han, Kunkun, Zhu, Jingyu, Mao, Hongwu, Lin, Xu, Zhang, Zubin, Cao, Biyin, Zeng, Yuanying, Mao, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342759/
https://www.ncbi.nlm.nih.gov/pubmed/27705908
http://dx.doi.org/10.18632/oncotarget.12265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342759/
https://www.ncbi.nlm.nih.gov/pubmed/27705908
http://dx.doi.org/10.18632/oncotarget.12265

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