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An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway

The activated JAK2-STAT3 signaling pathway is a high risk factor for multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, SC09, a potential inhibitor of cholesterol absorption, was identified in a STAT3-targeted drug screen. SC09 suppressed the activation of STAT3 in a ti...

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Detalles Bibliográficos
Autores principales:	Xu, Xin, Han, Kunkun, Zhu, Jingyu, Mao, Hongwu, Lin, Xu, Zhang, Zubin, Cao, Biyin, Zeng, Yuanying, Mao, Xinliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342759/ https://www.ncbi.nlm.nih.gov/pubmed/27705908 http://dx.doi.org/10.18632/oncotarget.12265

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