PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

Cancer including melanoma may be “addicted” to double strand break (DSB) repair and targeting this process could sensitize them to the lethal effect of DNA damage. PARP1 exerts an important impact on DSB repair as it binds to both single- and double- strand breaks. PARP1 inhibitors might be highly e...

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Detalles Bibliográficos
Autores principales: Czyż, Małgorzata, Toma, Monika, Gajos-Michniewicz, Anna, Majchrzak, Kinga, Hoser, Grazyna, Szemraj, Janusz, Nieborowska-Skorska, Margaret, Cheng, Phil, Gritsyuk, Daniel, Levesque, Mitchell, Dummer, Reinhard, Sliwinski, Tomasz, Skorski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342760/
https://www.ncbi.nlm.nih.gov/pubmed/27705909
http://dx.doi.org/10.18632/oncotarget.12270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342760/
https://www.ncbi.nlm.nih.gov/pubmed/27705909
http://dx.doi.org/10.18632/oncotarget.12270

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