Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development

E2F/RB activity is altered in most human tumors. The retinoblastoma family of proteins plays a key role in regulating the progression of the cell cycle from the G1 to S phases. This is achieved through negative regulation of E2F transcription factors, important positive regulators of cell cycle entr...

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Detalles Bibliográficos
Autores principales: Costa, Clotilde, Santos, Mirentxu, Martínez-Fernández, Mónica, Lorz, Corina, Lázaro, Sara, Paramio, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342772/
https://www.ncbi.nlm.nih.gov/pubmed/27708231
http://dx.doi.org/10.18632/oncotarget.12362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342772/
https://www.ncbi.nlm.nih.gov/pubmed/27708231
http://dx.doi.org/10.18632/oncotarget.12362

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