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Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
E2F/RB activity is altered in most human tumors. The retinoblastoma family of proteins plays a key role in regulating the progression of the cell cycle from the G1 to S phases. This is achieved through negative regulation of E2F transcription factors, important positive regulators of cell cycle entr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342772/ https://www.ncbi.nlm.nih.gov/pubmed/27708231 http://dx.doi.org/10.18632/oncotarget.12362 |