Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy

RECQ helicases are a family of enzymes with both over lapping and unique functions. Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that R...

Descripción completa

Detalles Bibliográficos
Autores principales: Patterson, Karl, Arya, Lovleen, Bottomley, Sarah, Morgan, Susan, Cox, Angela, Catto, James, Bryant, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342802/
https://www.ncbi.nlm.nih.gov/pubmed/27764811
http://dx.doi.org/10.18632/oncotarget.12683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342802/
https://www.ncbi.nlm.nih.gov/pubmed/27764811
http://dx.doi.org/10.18632/oncotarget.12683

Ejemplares similares