The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity

Nuclear factor erythroid 2-related factor 2 (Nrf2) provides a cellular defense against oxidative stress by inducing the expression of antioxidant and detoxification enzymes. The calcium antagonist, verapamil, is an FDA-approved drug prescribed for the treatment of hypertension. Here, we show that ve...

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Detalles Bibliográficos
Autores principales: Lee, Da Hyun, Park, Jeong Su, Lee, Yu Seol, Sung, Su Haeng, Lee, Yong-ho, Bae, Soo Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342872/
https://www.ncbi.nlm.nih.gov/pubmed/27998394
http://dx.doi.org/10.5483/BMBRep.2017.50.2.188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342872/
https://www.ncbi.nlm.nih.gov/pubmed/27998394
http://dx.doi.org/10.5483/BMBRep.2017.50.2.188

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