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Chronic Ca(2+) influx through voltage-dependent Ca(2+) channels enhance delayed rectifier K(+) currents via activating Src family tyrosine kinase in rat hippocampal neurons

Excessive influx and the subsequent rapid cytosolic elevation of Ca(2+) in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regul...

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Detalles Bibliográficos
Autores principales: Yang, Yoon-Sil, Jeon, Sang-Chan, Kim, Dong-Kwan, Eun, Su-Yong, Jung, Sung-Cherl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343060/
https://www.ncbi.nlm.nih.gov/pubmed/28280420
http://dx.doi.org/10.4196/kjpp.2017.21.2.259