Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis

Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellula...

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Detalles Bibliográficos
Autores principales: Dianzani, Chiara, Bellavista, Elena, Liepe, Juliane, Verderio, Claudia, Martucci, Morena, Santoro, Aurelia, Chiocchetti, Annalisa, Luca Gigliotti, Casimiro, Boggio, Elena, Ferrara, Benedetta, Riganti, Loredana, Keller, Christin, Janek, Katharina, Niewienda, Agathe, Fenoglio, Chiara, Sorosina, Melissa, Cantello, Roberto, Kloetzel, Peter M., Stumpf, Michael P. H., Paul, Friedemann, Ruprecht, Klemens, Galimberti, Daniela, Martinelli Boneschi, Filippo, Comi, Cristoforo, Dianzani, Umberto, Mishto, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343429/
https://www.ncbi.nlm.nih.gov/pubmed/28276434
http://dx.doi.org/10.1038/srep43718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343429/
https://www.ncbi.nlm.nih.gov/pubmed/28276434
http://dx.doi.org/10.1038/srep43718

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