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Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca(2+) signaling in human retinal pigment epithelial cells

Vertebrate eyes are known to contain circadian clocks, however, the intracellular mechanisms regulating the retinal clockwork remain largely unknown. To address this, we generated a cell line (hRPE-YC) from human retinal pigmental epithelium, which stably co-expressed reporters for molecular clock o...

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Detalles Bibliográficos
Autores principales: Ikarashi, Rina, Akechi, Honami, Kanda, Yuzuki, Ahmad, Alsawaf, Takeuchi, Kouhei, Morioka, Eri, Sugiyama, Takashi, Ebisawa, Takashi, Ikeda, Masaaki, Ikeda, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343479/
https://www.ncbi.nlm.nih.gov/pubmed/28276525
http://dx.doi.org/10.1038/srep44175