Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

Sequence divergence of orthologous proteins enables adaptation to environmental stresses and promotes evolution of novel functions. Limits on evolution imposed by constraints on sequence and structure were explored using a model TIM barrel protein, indole-3-glycerol phosphate synthase (IGPS). Fitnes...

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Detalles Bibliográficos
Autores principales: Chan, Yvonne H., Venev, Sergey V., Zeldovich, Konstantin B., Matthews, C. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343507/
https://www.ncbi.nlm.nih.gov/pubmed/28262665
http://dx.doi.org/10.1038/ncomms14614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343507/
https://www.ncbi.nlm.nih.gov/pubmed/28262665
http://dx.doi.org/10.1038/ncomms14614

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