High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating

[Image: see text] The mechanosensitive channels of large conductance (MscL) are bacterial membrane proteins that serve as last resort emergency release valves in case of severe osmotic downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer environment and are, ther...

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Detalles Bibliográficos
Autores principales: Melo, Manuel N., Arnarez, Clément, Sikkema, Hendrik, Kumar, Neeraj, Walko, Martin, Berendsen, Herman J. C., Kocer, Armagan, Marrink, Siewert J., Ingólfsson, Helgi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343553/
https://www.ncbi.nlm.nih.gov/pubmed/28122455
http://dx.doi.org/10.1021/jacs.6b11091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343553/
https://www.ncbi.nlm.nih.gov/pubmed/28122455
http://dx.doi.org/10.1021/jacs.6b11091

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