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High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating
[Image: see text] The mechanosensitive channels of large conductance (MscL) are bacterial membrane proteins that serve as last resort emergency release valves in case of severe osmotic downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer environment and are, ther...
Autores principales: | Melo, Manuel N., Arnarez, Clément, Sikkema, Hendrik, Kumar, Neeraj, Walko, Martin, Berendsen, Herman J. C., Kocer, Armagan, Marrink, Siewert J., Ingólfsson, Helgi I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343553/ https://www.ncbi.nlm.nih.gov/pubmed/28122455 http://dx.doi.org/10.1021/jacs.6b11091 |
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