Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin

Endoplasmic reticulum (ER) stress is increasingly identified as modulator of fibrosis. Losartan, an angiotensin II receptor blocker, has been widely used as the first choice of treatment in chronic renal diseases. We postulated that anti-fibrotic effect of losartan is mediated through inhibition of...

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Detalles Bibliográficos
Autores principales: Kim, Hyosang, Baek, Chung Hee, Lee, Raymond Bok, Chang, Jai Won, Yang, Won Seok, Lee, Sang Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343841/
https://www.ncbi.nlm.nih.gov/pubmed/28146117
http://dx.doi.org/10.3390/ijms18020305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343841/
https://www.ncbi.nlm.nih.gov/pubmed/28146117
http://dx.doi.org/10.3390/ijms18020305

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