Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain

The Asn-Gly-Arg (NGR) motif and its deamidation product isoAsp-Gly-Arg (isoDGR) have recently attracted considerable attention as tumor-targeting ligands. Because an NGR-containing peptide and the corresponding isoDGR-containing peptide target different receptors, the spontaneous NGR deamidation can...

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Detalles Bibliográficos
Autores principales: Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343963/
https://www.ncbi.nlm.nih.gov/pubmed/28212316
http://dx.doi.org/10.3390/ijms18020429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343963/
https://www.ncbi.nlm.nih.gov/pubmed/28212316
http://dx.doi.org/10.3390/ijms18020429

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