Exome Sequencing in a Family with Luminal-Type Breast Cancer Underpinned by Variation in the Methylation Pathway

Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain clinical significance (VUS). There is also no consensus on the selection criteria for WES. I...

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Detalles Bibliográficos
Autores principales: van der Merwe, Nicole, Peeters, Armand V., Pienaar, Fredrieka M., Bezuidenhout, Juanita, van Rensburg, Susan J., Kotze, Maritha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343999/
https://www.ncbi.nlm.nih.gov/pubmed/28241424
http://dx.doi.org/10.3390/ijms18020467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343999/
https://www.ncbi.nlm.nih.gov/pubmed/28241424
http://dx.doi.org/10.3390/ijms18020467

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