Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca(2+) Regulation

Reduced cardiomyocyte excitation–contraction coupling and downregulation of the SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gene therapy...

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Detalles Bibliográficos
Autores principales: Shanks, Julia, Herring, Neil, Johnson, Errin, Liu, Kun, Li, Dan, Paterson, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344179/
https://www.ncbi.nlm.nih.gov/pubmed/28223472
http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344179/
https://www.ncbi.nlm.nih.gov/pubmed/28223472
http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08507

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