Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy

Retroviral vector gene therapy is a promising approach to treating HIV-1. However, integrated vectors are mutagens with the potential to dysregulate nearby genes and cause severe adverse side effects. Leukemia has already been a documented severe adverse event in gene therapy clinical trials for the...

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Detalles Bibliográficos
Autores principales: Browning, Diana L., Trobridge, Grant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344246/
https://www.ncbi.nlm.nih.gov/pubmed/28424756
http://dx.doi.org/10.3390/biomedicines4010004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344246/
https://www.ncbi.nlm.nih.gov/pubmed/28424756
http://dx.doi.org/10.3390/biomedicines4010004

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