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Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy
Retroviral vector gene therapy is a promising approach to treating HIV-1. However, integrated vectors are mutagens with the potential to dysregulate nearby genes and cause severe adverse side effects. Leukemia has already been a documented severe adverse event in gene therapy clinical trials for the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344246/ https://www.ncbi.nlm.nih.gov/pubmed/28424756 http://dx.doi.org/10.3390/biomedicines4010004 |