A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...

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Detalles Bibliográficos
Autores principales: Forés, Marta, Simón-Carrasco, Lucía, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Drosten, Matthias, Barbacid, Mariano, Jiménez, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344332/
https://www.ncbi.nlm.nih.gov/pubmed/28278156
http://dx.doi.org/10.1371/journal.pgen.1006622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344332/
https://www.ncbi.nlm.nih.gov/pubmed/28278156
http://dx.doi.org/10.1371/journal.pgen.1006622

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