The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

Tetratricopeptide (TPR) domains are known protein interaction domains. We show that the TPR domain of FKBP8 selectively binds Hsp90, and interactions upstream of the conserved MEEVD motif are critical for tight binding. In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Blundell, Katie L. I. M., Pal, Mohinder, Roe, S. Mark, Pearl, Laurence H., Prodromou, Chrisostomos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344419/
https://www.ncbi.nlm.nih.gov/pubmed/28278223
http://dx.doi.org/10.1371/journal.pone.0173543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344419/
https://www.ncbi.nlm.nih.gov/pubmed/28278223
http://dx.doi.org/10.1371/journal.pone.0173543

Ejemplares similares