Cargando…
The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90
Tetratricopeptide (TPR) domains are known protein interaction domains. We show that the TPR domain of FKBP8 selectively binds Hsp90, and interactions upstream of the conserved MEEVD motif are critical for tight binding. In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essenti...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344419/ https://www.ncbi.nlm.nih.gov/pubmed/28278223 http://dx.doi.org/10.1371/journal.pone.0173543 |