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Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice
Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Fas(lpr) murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on Fas-deficiency rather than lupus-promoting...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344451/ https://www.ncbi.nlm.nih.gov/pubmed/28278279 http://dx.doi.org/10.1371/journal.pone.0173471 |