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Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice

Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Fas(lpr) murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on Fas-deficiency rather than lupus-promoting...

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Detalles Bibliográficos
Autores principales:	Nickerson, Kevin M., Wang, Yujuan, Bastacky, Sheldon, Shlomchik, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344451/ https://www.ncbi.nlm.nih.gov/pubmed/28278279 http://dx.doi.org/10.1371/journal.pone.0173471

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