Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells – Effects on gene expression levels and thiopurine metabolism

Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile. In red blood cells in vivo, it reduces the concentration of methylated metabolites and increases the conce...

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Detalles Bibliográficos
Autores principales: Haglund, Sofie, Vikingsson, Svante, Almer, Sven, Söderman, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344510/
https://www.ncbi.nlm.nih.gov/pubmed/28278299
http://dx.doi.org/10.1371/journal.pone.0173825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344510/
https://www.ncbi.nlm.nih.gov/pubmed/28278299
http://dx.doi.org/10.1371/journal.pone.0173825

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