Dissecting Target Toxic Tissue and Tissue Specific Responses of Irinotecan in Rats Using Metabolomics Approach

As an anticancer agent, irinotecan (CPT-11) has been widely applied in clinical, especially in the treatment of colorectal cancer. However, its clinical use has long been limited by the side effects and potential tissue toxicity. To discriminate the target toxic tissues and dissect the specific resp...

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Detalles Bibliográficos
Autores principales: Yao, Yiran, Zhang, Pei, Wang, Jing, Chen, Jiaqing, Wang, Yong, Huang, Yin, Zhang, Zunjian, Xu, Fengguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344918/
https://www.ncbi.nlm.nih.gov/pubmed/28344557
http://dx.doi.org/10.3389/fphar.2017.00122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344918/
https://www.ncbi.nlm.nih.gov/pubmed/28344557
http://dx.doi.org/10.3389/fphar.2017.00122

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