DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344974/
https://www.ncbi.nlm.nih.gov/pubmed/28270689
http://dx.doi.org/10.1038/ncomms14712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344974/
https://www.ncbi.nlm.nih.gov/pubmed/28270689
http://dx.doi.org/10.1038/ncomms14712

Ejemplares similares