Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal. Here we show superior preparations of antigens in dimethylsulfoxide, avoidi...

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Detalles Bibliográficos
Autores principales: Mak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong, Fairlie, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344979/
https://www.ncbi.nlm.nih.gov/pubmed/28272391
http://dx.doi.org/10.1038/ncomms14599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344979/
https://www.ncbi.nlm.nih.gov/pubmed/28272391
http://dx.doi.org/10.1038/ncomms14599

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