Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

BACKGROUND: Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit from a novel therapy preventing or reversing these changes. To this end, we hav...

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Detalles Bibliográficos
Autores principales: Roberts, Cai M., Shahin, Sophia A., Loeza, Joana, Dellinger, Thanh H., Williams, John C., Glackin, Carlotta A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345230/
https://www.ncbi.nlm.nih.gov/pubmed/28283022
http://dx.doi.org/10.1186/s12885-017-3169-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345230/
https://www.ncbi.nlm.nih.gov/pubmed/28283022
http://dx.doi.org/10.1186/s12885-017-3169-9

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