Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma

A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the m...

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Detalles Bibliográficos
Autores principales: Ewens, Kathryn G., Bhatti, Tricia R., Moran, Kimberly A., Richards‐Yutz, Jennifer, Shields, Carol L., Eagle, Ralph C., Ganguly, Arupa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345671/
https://www.ncbi.nlm.nih.gov/pubmed/28211617
http://dx.doi.org/10.1002/cam4.1010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345671/
https://www.ncbi.nlm.nih.gov/pubmed/28211617
http://dx.doi.org/10.1002/cam4.1010

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