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A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans

When mutations have small effects on fitness, population size plays an important role in determining the amount and nature of deleterious genetic variation. The extent to which recent population size changes have impacted deleterious variation in humans has been a question of considerable interest a...

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Detalles Bibliográficos
Autores principales: Koch, Evan, Novembre, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345704/
https://www.ncbi.nlm.nih.gov/pubmed/28159863
http://dx.doi.org/10.1534/g3.117.039651