Cargando…

A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles

Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington’s Disease (HD) that is caused by a polyglutamine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Amy L., Ung, Hailey M., Sands, L. Paul, Kikis, Elise A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345860/ https://www.ncbi.nlm.nih.gov/pubmed/28282438 http://dx.doi.org/10.1371/journal.pone.0173644

Ejemplares similares

Chemical mutagenesis of Caenorhabditis elegans uncovers genetic modifiers of huntingtin protein aggregation
por: Ung, Hailey M., et al.
Publicado: (2020)

Genetic background modulates the sensitivity of Caenorhabditis elegans to the toxic effects of vehicular air pollution
por: Garcia Manriquez, Bailey A., et al.
Publicado: (2022)

The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease
por: Kikis, Elise A.
Publicado: (2016)

Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans
por: Green, Emily H., et al.
Publicado: (2020)

Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans
Publicado: (1994)

Nanoparticulate air pollution disrupts proteostasis in Caenorhabditis elegans
por: Garcia Manriquez, Bailey A., et al.
Publicado: (2023)

α spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans
por: Norman, Kenneth R., et al.
Publicado: (2002)

Optical silencing of body wall muscles induces pumping inhibition in Caenorhabditis elegans
por: Takahashi, Megumi, et al.
Publicado: (2017)

Determining the Sub-Cellular Localization of Proteins within Caenorhabditis elegans Body Wall Muscle
por: Meissner, Barbara, et al.
Publicado: (2011)

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation
por: Teuling, Eva, et al.
Publicado: (2011)

Heat-Induced Calcium Leakage Causes Mitochondrial Damage in Caenorhabditis elegans Body-Wall Muscles
por: Momma, Kenta, et al.
Publicado: (2017)

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease
por: Zeng, Yixuan, et al.
Publicado: (2016)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

UNC-60B, an ADF/Cofilin Family Protein, Is Required for Proper Assembly of Actin into Myofibrils in Caenorhabditis elegans Body Wall Muscle
por: Ono, Shoichiro, et al.
Publicado: (1999)

Age-dependent accumulation of tau aggregation in Caenorhabditis elegans
por: Aquino Nunez, Wendy, et al.
Publicado: (2022)

Sequestration of Sup35 by Aggregates of huntingtin Fragments Causes Toxicity of [PSI(+)] Yeast
por: Zhao, Xiaohong, et al.
Publicado: (2012)

Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast
por: Kantcheva, Ralitsa B., et al.
Publicado: (2014)

The L-type voltage-dependent Ca(2+) channel EGL-19 controls body wall muscle function in Caenorhabditis elegans
por: Jospin, Maëlle, et al.
Publicado: (2002)

Muscle cell attachment in Caenorhabditis elegans
Publicado: (1991)

The embryonic muscle transcriptome of Caenorhabditis elegans
por: Fox, Rebecca M, et al.
Publicado: (2007)

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
por: Ayyadevara, Srinivas, et al.
Publicado: (2016)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

Effect of aspect ratio on the uptake and toxicity of hydroxylated-multi walled carbon nanotubes in the nematode, Caenorhabditis elegans
por: Eom, Hyun-Jeong, et al.
Publicado: (2015)

Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans
por: Jiang, Hongbing, et al.
Publicado: (2020)

Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans
por: Izquierdo, Patricia G., et al.
Publicado: (2021)

Gene Expression Modifications by Temperature-Toxicants Interactions in Caenorhabditis elegans
por: Viñuela, Ana, et al.
Publicado: (2011)

Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis elegans
por: Murphy, John T., et al.
Publicado: (2011)

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity
por: Xu, Fangke, et al.
Publicado: (2019)

Molecular characterization of ethyl carbamate toxicity in Caenorhabditis elegans
por: Comfort, Jordan J., et al.
Publicado: (2022)

TRiC’s tricks inhibit huntingtin aggregation
por: Shahmoradian, Sarah H, et al.
Publicado: (2013)

Detection of ubiquitinated huntingtin species in intracellular aggregates
por: Juenemann, Katrin, et al.
Publicado: (2015)

Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
por: Wang, Chuan-En, et al.
Publicado: (2008)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Sideritis scardica extracts inhibit aggregation and toxicity of amyloid-β in Caenorhabditis elegans used as a model for Alzheimer’s disease
por: Heiner, Felix, et al.
Publicado: (2018)

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model
por: Van Assche, Roel, et al.
Publicado: (2017)

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
por: He, Wen-Tian, et al.
Publicado: (2017)

Works at building 513
Publicado: (2003)

Works at building 513
Publicado: (2003)

Works at building 513
Publicado: (2003)

B513 roof
por: Grossir, Anthony
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_i9045e8oo1umk4s34ipcvd2nlb