Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP

The African swine fever virus DP71L protein recruits protein phosphatase 1 (PP1) to dephosphorylate the translation initiation factor 2α (eIF2α) and avoid shut-off of global protein synthesis and downstream activation of the pro-apoptotic factor CHOP. Residues V16 and F18A were critical for binding...

Descripción completa

Detalles Bibliográficos
Autores principales: Barber, Claire, Netherton, Chris, Goatley, Lynnette, Moon, Alice, Goodbourn, Steve, Dixon, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346070/
https://www.ncbi.nlm.nih.gov/pubmed/28189088
http://dx.doi.org/10.1016/j.virol.2017.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346070/
https://www.ncbi.nlm.nih.gov/pubmed/28189088
http://dx.doi.org/10.1016/j.virol.2017.02.002

Ejemplares similares