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Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action

Parkinson’s disease (PD) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (DAergic) neurons of the substantia nigra (SN) and the accumulation of intracellular inclusions containing α-synuclein. Current therapies do not stop the progression of the disease, and the ef...

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Detalles Bibliográficos
Autores principales: Voutilainen, Merja H., De Lorenzo, Francesca, Stepanova, Polina, Bäck, Susanne, Yu, Li-Ying, Lindholm, Päivi, Pörsti, Eeva, Saarma, Mart, Männistö, Pekka T., Tuominen, Raimo K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346176/
https://www.ncbi.nlm.nih.gov/pubmed/28303260
http://dx.doi.org/10.1523/ENEURO.0117-16.2017